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. 2016 Mar 26;7(6):694-701.
doi: 10.7150/jca.14185. eCollection 2016.

Pathologic Diagnosis of Pancreatic Adenocarcinoma in the United States: Its Status and Prognostic Value

Miaozhen Qiu  1 , Huijuan Qiu  2 , Ying Jin  3 , Xiaoli Wei  3 , Yixin Zhou  2 , Zixian Wang  3 , Deshen Wang  3 , Chao Ren  3 , Huiyan Luo  3 , Feng Wang  3 , Dongsheng Zhang  3 , Fenghua Wang  3 , Yuhong Li  3 , Dajun Yang  4 , Ruihua Xu  3
Affiliations

Pathologic Diagnosis of Pancreatic Adenocarcinoma in the United States: Its Status and Prognostic Value

Miaozhen Qiu et al. J Cancer. .

Abstract

Purpose: Even with the development of new biopsy methods, diagnosis of pancreatic cancer is sometimes without histological evidence. The aim of our study is to find out the status of pancreatic cancer patients who are diagnosed without pathologic confirm and the prognostic value of pathologic diagnosis.

Methods: We identified 52,759 pancreatic adenocarcinoma patients from the Surveillance, Epidemiology, and End RESULTS (SEER) database. Logistic regression model was used to identify factors relating to no pathologic diagnosis. Multivariable Cox regression model identified potential prognostic factors. All statistical tests were two-sided.

Results: There were 6206 (11.76%) patients without pathologic diagnosis. Older age, reported from nursing/convalescent home/hospice or physician's office/private medical practitioner, early year of diagnosis, larger tumor size, pancreatic head cancer, unmarried patients, uninsured and stage I disease all contributed to no pathologic diagnosis. Median cause specific-survival for patients with and without pathologic diagnosis were 7.72 and 3.52 months, respectively. The HR for pathologic diagnosis was 0.92 (95% CI: 0.89-0.95), P<0.001.

Conclusions: Pathologic diagnosis was an independent prognostic factor for pancreatic adenocarcinoma patients. New diagnostic methods are needed to get the pathologic diagnosis.

Keywords: Pancreatic adenocarcinoma; Pathologic diagnosis; Prognosis; SEER..

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Conflict of interest statement

Conflict of Interest: All authors declared that there is no conflict of interest.

Figures

Figure 1
Figure 1
Survival difference between patients with and without pathologic diagnosis.
See this image and copyright information in PMC

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