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Comment
. 2016 Feb 2:5:26-7.
doi: 10.1016/j.ebiom.2016.02.003. eCollection 2016 Mar.

Targeting Tissue Lipids in Age-related Macular Degeneration

Rajendra S Apte  1
Affiliations
Comment

Targeting Tissue Lipids in Age-related Macular Degeneration

Rajendra S Apte. EBioMedicine. .
No abstract available

Keywords: AMD; Cholesterol; Eye; Inflammation; Lipids; Macular degeneration; Retina; macrophage.

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Figures

Fig. 1
Fig. 1
Natural history of age-related macular degeneration (AMD) and potential role of lipid targeted therapies. Early AMD is characterized by lipid rich drusen, sub-retinal drusenoid deposits, and thickening of Bruch's membrane (BM) along with abnormalities in the retinal pigmented epithelium (RPE). Macrophage-mediated inflammation, complement activation as manifested by the deposition of membrane attack complexes (MAC), and RPE dysfunction lead to advanced disease characterized by choroidal neovascularization (CNV) and geographic atrophy (GA). Potential therapeutic approaches to prevent complications of AMD are highlighted. PR = photoreceptor neurons.
See this image and copyright information in PMC

Comment in

  • Macular degeneration.
    [No authors listed] [No authors listed] Nurs Older People. 2016 May;28(4):13. doi: 10.7748/nop.28.4.13.s16. Nurs Older People. 2016. PMID: 27125936 No abstract available.

Comment on

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