Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 May;57(5):1351-5.
doi: 10.1128/iai.57.5.1351-1355.1989.

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

D M Williams  1 , L F Bonewald, G D Roodman, G I Byrne, D M Magee, J Schachter
Affiliations

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

D M Williams et al. Infect Immun. 1989 May.

Abstract

A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice (nu/+) produced tumor necrosis factor alpha in vitro in response to mouse pneumonitis agent antigen. The tumor necrosis factor alpha measured in these supernatants by immunoassay was shown to have bioactivity in a cytotoxic assay in which uninfected target cells were used. This cytotoxicity was distinct from the gamma interferon-related cytotoxicity against C. trachomatis-infected targets that we described previously.

PubMed Disclaimer

References

    1. J Immunol. 1985 Sep;135(3):2069-73 - PubMed
    1. Cell Immunol. 1985 May;92(2):218-25 - PubMed
    1. Rev Infect Dis. 1985 Nov-Dec;7(6):717-25 - PubMed
    1. Rev Infect Dis. 1985 Nov-Dec;7(6):754-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667-71 - PubMed

Publication types

MeSH terms