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Randomized Controlled Trial
. 2016 Aug 1;44(8):948-9.
doi: 10.1016/j.ajic.2016.02.019. Epub 2016 Apr 11.

Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?

Margaret McCann  1 , Fidelma Fitzpatrick  2 , George Mellotte  3 , Michael Clarke  4
Affiliations
Randomized Controlled Trial

Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?

Margaret McCann et al. Am J Infect Control. .

Abstract

A pilot randomized trial in 3 Irish outpatient hemodialysis units compared 2% chlorhexidine gluconate (CHG) in 70% isopropyl alcohol with routinely used CHG solutions for central venous catheter exit site antisepsis. We found no significant difference between the groups for the prevention of catheter-related bloodstream infections (1/53 vs 2/52; relative risk [RR], 0.49; 95% confidence interval [CI], 0.05-5.25; P = .55) and catheter-associated bloodstream infections (1/53 vs 4/52; RR, 0.25; 95% CI, 0.03-2.12; P = .16).

Keywords: Hemodialysis; central venous catheters; chlorhexidine gluconate; clinical trial; infection prevention; skin cleansing.

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