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Randomized Controlled Trial
. 2016 Jun:173:245-249.e4.
doi: 10.1016/j.jpeds.2016.03.026. Epub 2016 Apr 11.

High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial

Kitty G Snoek  1 , Ulrike S Kraemer  1 , Chantal A Ten Kate  1 , Anne Greenough  2 , Arno van Heijst  3 , Irma Capolupo  4 , Thomas Schaible  5 , Joost van Rosmalen  6 , René M Wijnen  1 , Irwin K M Reiss  7 , Dick Tibboel  1
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Randomized Controlled Trial

High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial

Kitty G Snoek et al. J Pediatr. 2016 Jun.

Abstract

Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia.

Trial registration: Netherlands Trial Registry: 1310.

Keywords: Biomarkers; pulmonary hypertension.

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