The role of innate immunity in the immunopathology and treatment of HBV infection

Abstract

In this review we give a brief update on sensors recently determined to be capable of detecting HBV, and examine how the virus represses the induction of pro-inflammatory cytokines like type I interferons. We overview cellular components of innate immunity that are present at high frequencies in the liver, and discuss their roles in HBV control and/or pathogenesis. We argue that many innate effectors have adaptive-like features or can exert specific effects on HBV through immunoregulation of T cells. Finally we consider current and possible future strategies to manipulate innate immunity as novel approaches towards a functional cure for HBV.

Keywords: HBV innate immunity; Innate immunotherapy; Innate sensors; Interferon-alpha; MAITs; MDSC; Monocytes; NK cells.