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Review
. 2016 Jun;119(3):423-31.
doi: 10.1016/j.radonc.2016.03.013. Epub 2016 Apr 12.

Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer

Cathy Fleming  1 , Daniel N Cagney  2 , Serena O'Keeffe  1 , Sinead M Brennan  2 , John G Armstrong  2 , Brendan McClean  3
Affiliations
Review

Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer

Cathy Fleming et al. Radiother Oncol. 2016 Jun.

Abstract

Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose-volume-constraints (DVCs) published in the literature refer to conventional 2Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose-volume constraint data discussed and summarised for moderately hypofractionated NSCLC regimes. The OARs examined include lung, brachial plexus, heart, oesophagus, airway and spinal cord. Where available the toxicity rates are also reported with all data summarised tabulated to aid its use in the clinic.

Keywords: DVCs; Dose–volume constraints; Hypofractionated; NSCLC; Toxicity.

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