(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China

Zhao Chen¹, Caifa Zheng¹, Zhe Long¹, Li Cao², Xunhua Li³, Huifang Shang⁴, Xinzhen Yin⁵, Baorong Zhang⁵, Jingyu Liu⁶, Dongxue Ding¹, Yun Peng¹, Chunrong Wang¹, Huirong Peng¹, Wei Ye¹, Rong Qiu⁷, Qian Pan⁸, Kun Xia⁸, Shengdi Chen², Jorge Sequeiros⁹, Tetsuo Ashizawa¹⁰, Thomas Klockgether¹¹, Beisha Tang¹², Hong Jiang¹³; Chinese Clinical Research Cooperative Group for Spinocerebellar Ataxias (CCRCG-SCA)

Affiliations

¹ 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China.
² 2 Department of Neurology and Institute of Neurology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China.
³ 3 Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P. R. China.
⁴ 4 Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
⁵ 5 Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, P. R. China.
⁶ 6 Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Centre for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.
⁷ 7 School of Information Science and Engineering, Central South University, Changsha, Hunan, 410083, P. R. China.
⁸ 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China.
⁹ 9 IBMC - Institute for Molecular and Cell Biology, i3S - Instituto de Investigação e Inovação na Saúde; and ICBAS; Univ. Porto, Portugal.
¹⁰ 10 Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
¹¹ 11 Department of Neurology, University Hospital of Bonn, Bonn, Germany.
¹² 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China 12 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China.
¹³ 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China 12 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China 13 Xinjiang Medical University, Xinjiang, 830011, P.R. China jianghong73868@126.com.

PMID: 27085188
DOI: 10.1093/brain/aww087

Comment

(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China

Zhao Chen et al. Brain. 2016 Aug.

. 2016 Aug;139(Pt 8):e41.

doi: 10.1093/brain/aww087. Epub 2016 Apr 16.

Authors

Affiliations

¹ 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China.
² 2 Department of Neurology and Institute of Neurology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China.
³ 3 Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P. R. China.
⁴ 4 Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
⁵ 5 Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, P. R. China.
⁶ 6 Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Centre for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.
⁷ 7 School of Information Science and Engineering, Central South University, Changsha, Hunan, 410083, P. R. China.
⁸ 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China.
⁹ 9 IBMC - Institute for Molecular and Cell Biology, i3S - Instituto de Investigação e Inovação na Saúde; and ICBAS; Univ. Porto, Portugal.
¹⁰ 10 Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
¹¹ 11 Department of Neurology, University Hospital of Bonn, Bonn, Germany.
¹² 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China 12 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China.
¹³ 1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China 12 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China 13 Xinjiang Medical University, Xinjiang, 830011, P.R. China jianghong73868@126.com.

PMID: 27085188
DOI: 10.1093/brain/aww087

No abstract available

PubMed Disclaimer

Comment on

Modulation of the age at onset in spinocerebellar ataxia by CAG tracts in various genes.
Tezenas du Montcel S, Durr A, Bauer P, Figueroa KP, Ichikawa Y, Brussino A, Forlani S, Rakowicz M, Schöls L, Mariotti C, van de Warrenburg BP, Orsi L, Giunti P, Filla A, Szymanski S, Klockgether T, Berciano J, Pandolfo M, Boesch S, Melegh B, Timmann D, Mandich P, Camuzat A; Clinical Research Consortium for Spinocerebellar Ataxia (CRC-SCA); EUROSCA network; Goto J, Ashizawa T, Cazeneuve C, Tsuji S, Pulst SM, Brusco A, Riess O, Brice A, Stevanin G. Tezenas du Montcel S, et al. Brain. 2014 Sep;137(Pt 9):2444-55. doi: 10.1093/brain/awu174. Epub 2014 Jun 26. Brain. 2014. PMID: 24972706 Free PMC article.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Silverchair Information Systems
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China

Affiliations

(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China

Authors

Affiliations

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources