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. 2016 Sep;18(9):823-30.
doi: 10.1080/10286020.2016.1170813. Epub 2016 Apr 19.

Four new diterpenoids isolated from the Euphorbia rapulum

Xiao-Xue Liu  1 , Lei Shang  2 , Chao Huang  3 , Xue-Song Feng  2 , Wen Li  3 , Yi Sha  3 , Jian Huang  1 , Jin-Hui Wang  1
Affiliations

Four new diterpenoids isolated from the Euphorbia rapulum

Xiao-Xue Liu et al. J Asian Nat Prod Res. 2016 Sep.

Abstract

Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM.

Keywords: Euphorbia rapulum; Euphorbiaceae; cytotoxic activities; diterpenoids.

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