Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;52(1):8-13.
doi: 10.1136/jnnp.52.1.8.

Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis

I Grant  1 , G W Brown, T Harris, W I McDonald, T Patterson, M R Trimble
Affiliations

Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis

I Grant et al. J Neurol Neurosurg Psychiatry. 1989 Jan.

Abstract

Information was obtained on stressful life circumstances, using the Life Events and Difficulties Schedule (LEDS) from 39 patients with early multiple sclerosis and 40 matched nonpatient volunteers. The proportion of multiple sclerosis patients who experienced marked life adversity in the year prior to onset of symptoms was significantly higher than for nonpatients in the year before interview (77% vs. 35%). The excess in marked life stress was most evident in the 6 months before onset. Such stressors might explain the timing of symptom exacerbation for some patients with multiple sclerosis, perhaps by perturbing an already unstable neuroimmunological system.

PubMed Disclaimer

References

    1. Psychosom Med. 1958 Nov-Dec;20(6):458-74 - PubMed
    1. J Chronic Dis. 1982;35(11):821-31 - PubMed
    1. Brain. 1987 Apr;110 ( Pt 2):405-14 - PubMed
    1. Psychosom Med. 1970 Jan-Feb;32(1):67-86 - PubMed
    1. Res Publ Assoc Res Nerv Ment Dis. 1950;28:456-60 - PubMed

Publication types