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Randomized Controlled Trial
. 2016 Jul:88:176-81.
doi: 10.1016/j.ypmed.2016.04.011. Epub 2016 Apr 16.

Predictors of cholesterol treatment discussions and statin prescribing for primary cardiovascular disease prevention in community health centers

Kunal N Karmali  1 , Ji-Young Lee  2 , Tiffany Brown  2 , Stephen D Persell  3
Affiliations
Randomized Controlled Trial

Predictors of cholesterol treatment discussions and statin prescribing for primary cardiovascular disease prevention in community health centers

Kunal N Karmali et al. Prev Med. 2016 Jul.

Abstract

Background: Although cholesterol guidelines emphasize cardiovascular disease (CVD) risk to guide primary prevention, predictors of statin use in practice are unknown. We aimed to identify factors associated with a cholesterol treatment discussion and statin prescribing in a high-risk population.

Methods: We used data from a trial conducted among participants in community health centers without CVD or diabetes and a 10-year coronary heart disease (CHD) risk≥10%. Cholesterol treatment discussion was assessed at 6months and statin prescription at 1year. We used logistic regressions to identify factors associated with each outcome.

Results: We analyzed 646 participants (89% male, mean age 60±9.5years). Cholesterol treatment discussion occurred in 19% and statin prescription in 12% of participants. Ten-year CHD risk was not associated with treatment discussion (OR 1.11 per 1 SD increase, 95% CI 0.91-1.33) but was associated with statin prescription (OR 1.41 per 1 SD increase, 95% CI 1.13-1.75) in unadjusted models. After adjusting for traditional CVD risk factors that contribute to CHD risk, low-density lipoprotein cholesterol (LDL-C) was independently associated with statin prescription (OR 1.82 per 1 SD increase, 95% CI 1.66-1.99). Antihypertensive medication use was independently associated with both cholesterol treatment discussion (OR 3.68, 95% CI 2.35-5.75) and statin prescription (OR 3.98, 95% CI 3.30-4.81). Other drivers of CVD risk (age, smoking, and systolic blood pressure) were not associated with statin use.

Conclusions: Single risk factor management strongly influences cholesterol treatment discussions and statin prescribing patterns. Interventions that promote risk-based statin utilization are needed.

Trial registration: Clinicaltrials.gov.: NCT01610609.

Keywords: Cardiovascular disease prevention; Cholesterol; Risk assessment.

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Figures

Figure
Figure
Percent of participants with statin prescription by LDL-C category and 10-year CHD risk category
See this image and copyright information in PMC

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