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. 2016 Jul;31(7):972-8.
doi: 10.1002/mds.26573. Epub 2016 Apr 19.

Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk

Srishti Shrestha  1 , Pamela L Lutsey  2 , Alvaro Alonso  2 , Xuemei Huang  3 , Thomas H Mosley Jr  4 , Honglei Chen  1
Affiliations

Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk

Srishti Shrestha et al. Mov Disord. 2016 Jul.

Abstract

Background: Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.

Methods: Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval, 0.58-1.90) for 20-30 ng/mL and 1.14 (95% confidence interval, 0.59- 2.23) for ≥30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up.

Conclusion: This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. © 2016 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; cohort study; vitamin D.

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Conflict of interest statement

Financial Disclosure/Conflict of Interest: No conflicts of interest are declared.

Figures

Figure 1
Figure 1
Flowchart depicting study participants selection for serum 25-hydroxyvitamin D and Parkinson’s disease analysis, Atherosclerosis Risk in Communities Study, 1990-1992. Abbreviations: PD, Parkinson’s disease; CVD, Cardiovascular disease.
See this image and copyright information in PMC

Comment in

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