Non-Genetic Transmission of Obesity - It's in Your Epigenes
- PMID: 27091491
- DOI: 10.1016/j.tem.2016.04.003
Non-Genetic Transmission of Obesity - It's in Your Epigenes
Abstract
Obesity and its related metabolic comorbidities can be inherited across generations through non-genetic mechanisms. In a recent report, Huypens et al., using an in vitro fertilization approach, provide evidence that exposure to a high-fat diet modifies egg and sperm epigenetic information, rendering the progeny more prone to obesity.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Comment on
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Epigenetic germline inheritance of diet-induced obesity and insulin resistance.Nat Genet. 2016 May;48(5):497-9. doi: 10.1038/ng.3527. Epub 2016 Mar 14. Nat Genet. 2016. PMID: 26974008
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