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Comment
. 2016 May;5(5):703.
doi: 10.5966/sctm.2015-0325.

What Should Be Chronic: The Animal, the Model, or Both?

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Comment

What Should Be Chronic: The Animal, the Model, or Both?

Gustavo A Rubio et al. Stem Cells Transl Med. 2016 May.

Abstract

The systematic review of mesenchymal stromal cell (MSC) therapy in pulmonary fibrosis by Srour and Thébaud published in a recent issue of Stem Cells Translational Medicine is critically reviewed; Rubio et al. suggest that bleomycin-induced lung injury in aged mice studied over time is a more clinically applicable model for human idiopathic pulmonary fibrosis.

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  • In Reply.
    Srour N, Thébaud B. Srour N, et al. Stem Cells Transl Med. 2016 May;5(5):703-4. doi: 10.5966/sctm.2015-0406. Stem Cells Transl Med. 2016. PMID: 27091589 Free PMC article.

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References

    1. Srour N, Thébaud B. Mesenchymal stromal cells in animal bleomycin pulmonary fibrosis models: A systematic review. Stem Cells Translational Medicine. 2015;4:1500–1510. - PMC - PubMed
    1. Peng R, Sridhar S, Tyagi G, et al. Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease. PLoS One. 2013;8:e59348. - PMC - PubMed
    1. Redente EF, Jacobsen KM, Solomon JJ, et al. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011;301:L510–L518. - PMC - PubMed
    1. Cordier JF, Cottin V. Neglected evidence in idiopathic pulmonary fibrosis: From history to earlier diagnosis. Eur Respir J. 2013;42:916–923. - PubMed
    1. Sueblinvong V, Neujahr DC, Mills ST, et al. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012;344:41–51. - PMC - PubMed