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Review
. 2016 Feb 15:15:134-43.
doi: 10.17179/excli2014-585. eCollection 2016.

Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis

Amir Asri  1 , Javid Sabour  1 , Amir Atashi  1 , Masoud Soleimani  1
Affiliations
Review

Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis

Amir Asri et al. EXCLI J. .

Abstract

Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a has been shown to bind CXCR7 in addition to CXCR4 and can also function as SDF1a/CXCR4 modulator. CXCR7 plays a role in HSCs homing via SDF1a gradient and is a mediator of CXCR4/SDF1a axis. This review describes the current concepts and questions concerning CXCR7/CXCR4/SDF1a axis as an important key in hematopoietic stem cells homing with particular emphasis on CXCR7 receptor. Homing of HSCs is an essential step for successful hematopoietic stem cell transplantation.

Keywords: CXCL12; CXCR4; CXCR7; HSCs homing.

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Figures

Figure 1
Figure 1. Schematic structure of CXCR4 and CXCR7: CXCR4 and CXCR7 are 7TMRs that share binding to SDF1a. CXCR7 also binds to I-TAC. “DRYLAIV” is a common motif in GPCRs modified to “DRYLSIT” motif essential for G-protein responses. SDF1a/CXCR7 interactions recruit Beta-arrestin but not G-protein.
Figure 2
Figure 2. CXCR7, CXCR4 and CXCR7/CXCR4 hetrodimerization signaling pathways
See this image and copyright information in PMC

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