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. 2016:2016:7239692.
doi: 10.1155/2016/7239692. Epub 2016 Mar 22.

Incidence of Type 1 Diabetes among Children and Adolescents in Italy between 2009 and 2013: The Role of a Regional Childhood Diabetes Registry

F Fortunato  1 , M G Cappelli  1 , M M Vece  1 , G Caputi  2 , M Delvecchio  3 , R Prato  1 , D Martinelli  1 ; Apulian Childhood-Onset Diabetes Registry Workgroup  4
Collaborators, Affiliations

Incidence of Type 1 Diabetes among Children and Adolescents in Italy between 2009 and 2013: The Role of a Regional Childhood Diabetes Registry

F Fortunato et al. J Diabetes Res. 2016.

Abstract

Background: Surveillance represents a key strategy to control type 1 diabetes mellitus (T1DM). In Italy, national data are missing. This study aimed at evaluating the incidence of T1DM in subjects <18 year olds in Apulia (a large southeastern region, about 4,000,000 inhabitants) and assessing the sensitivity of the regional Registry of Childhood-Onset Diabetes (RCOD) in the 2009-2013 period.

Methods: We performed a retrospective study matching records from regional Hospital Discharge Registry (HDR), User Fee Exempt Registry (UFER), and Drugs Prescription Registry (DPR) and calculated T1DM incidence; completeness of each data source was also estimated. In order to assess the RCOD sensitivity we compared cases from the registry to those extracted from HDR-UFER-DPR matching.

Results: During 2009-2013, a total of 917 cases (about 184/year) in at least one of the three sources and an annual incidence of 25.2 per 100,000 were recorded, lower in infant, increasing with age and peaked in 5- to 9-year-olds. The completeness of DPR was 78.7%, higher than that of UFER (64.3%) and of HDR (59.6%). The RCOD's sensitivity was 39.05% (360/922; 95% CI: 34.01%-44.09%).

Conclusions: Apulia appeared as a high-incidence region. A full, active involvement of physicians working in paediatric diabetes clinics would be desirable to improve the RCOD performance.

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Figures

Figure 1
Figure 1
Flowchart of the creation of the total number of patients <18 years with T1DM (the Unique Database). Apulia, Italy, 2009–2013.
Figure 2
Figure 2
Contribution of HDR, UFER, and DPR to the creation of the total number of patients <18 years with T1DM (the Unique Database). Apulia, Italy, 2009–2013.
See this image and copyright information in PMC

Comment in

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