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Review
. 2016 Apr 15;17(4):573.
doi: 10.3390/ijms17040573.

Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma

Maximilian Seles  1 , Georg C Hutterer  2 , Tobias Kiesslich  3   4 , Karl Pummer  5 , Ioana Berindan-Neagoe  6   7   8 , Samantha Perakis  9 , Daniela Schwarzenbacher  10 , Michael Stotz  11 , Armin Gerger  12   13 , Martin Pichler  14   15
Affiliations
Review

Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma

Maximilian Seles et al. Int J Mol Sci. .

Abstract

Renal cell carcinoma (RCC) represents a deadly disease with rising mortality despite intensive therapeutic efforts. It comprises several subtypes in terms of distinct histopathological features and different clinical presentations. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts in the genome which vary in expression levels and length and perform diverse functions. They are involved in the inititation, evolution and progression of primary cancer, as well as in the development and spread of metastases. Recently, several lncRNAs were described in RCC. This review emphasises the rising importance of lncRNAs in RCC. Moreover, it provides an outlook on their therapeutic potential in the future.

Keywords: long non-coding RNAs; metastases; renal cell cancer-carcinoma.

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Figures

Figure 1
Figure 1
Schematic drawing showing different pathways with involvement of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). Green arrows indicate stimulation, red “T” indicates suppression, black vertical arrows indicate up- or down-regulation [57,63,64,72,73,74,75,76,77].
See this image and copyright information in PMC

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