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Case Reports
. 2016 Sep 5;33(3):251-3.
doi: 10.4274/tjh.2015.0433. Epub 2016 Apr 18.

A Case of Superwarfarin Poisoning Due to Repetitive Occupational Dermal Rodenticide Exposure in a Worker

Zehra Narlı Özdemir  1 , Uğur Şahin, Mustafa Merter, Mehmet Gündüz, Berna Ateşağaoğlu, Meral Beksaç
Affiliations
Case Reports

A Case of Superwarfarin Poisoning Due to Repetitive Occupational Dermal Rodenticide Exposure in a Worker

Zehra Narlı Özdemir et al. Turk J Haematol. .

Abstract
in English, Turkish

Superwarfarin poisoning is usually due to chronic occult small-dose exposures and can easily be misdiagnosed and may lead to serious complications. The diagnosis can be confirmed by a concordant history and analyses of blood and urine specimens with the liquid chromatography with tandem mass spectrometry (LC-MS/MS) technique. Several months of continuous treatment with high doses of daily oral vitamin K, as well as other supportive measures, are warranted, especially when repeated laboratory measurements to help predict the treatment period are not available. In this paper, a case of superwarfarin poisoning due to chronic repetitive occupational dermal exposure to commercial rodenticides is presented.

Süpervarfarin zehirlenmesi genellikle, fark edilmeyen küçük dozlarda kronik maruziyete bağlı olarak gelişir ve kolaylıkla yanlış tanı konarak ciddi komplikasyonlara yol açabilir. Tanı, uyumlu bir hikaye varlığında kan ve idrar örneklerinin sıvı kromatografisi ve tandem kitle spektrometresi (LC-MS/MS) tekniği ile analiz edilmesi yoluyla doğrulanabilir. Özellikle de, tedavi süresine karar verilebilmesi için tekrarlanan laboratuvar ölçümlerinin yapılmasının mümkün olmadığı durumlarda, aylar boyunca yüksek dozda günlük oral K vitamini verilmesi gereklidir. Bu yazıda, ticari rodentisitlerle tekrarlayan mesleksel deri maruziyetine bağlı olarak süpervarfarin zehirlenmesi gelişen bir olgu sunulmaktadır.

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Conflict of interest statement

The authors of this paper have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included.

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