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. 2017 Jan;144(1):95-115.
doi: 10.1017/S003118201600055X. Epub 2016 Apr 20.

Insights on adaptive and innate immunity in canine leishmaniosis

Shazia Hosein  1 , Damer P Blake  1 , Laia Solano-Gallego  2
Affiliations

Insights on adaptive and innate immunity in canine leishmaniosis

Shazia Hosein et al. Parasitology. 2017 Jan.

Abstract

Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.

Keywords: Canine leishmaniosis; T-cell mediated immunity; cytokine profiles; immunology; toll-like receptors.

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