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. 2016 Apr 1:595:28-32.
doi: 10.1016/j.abb.2015.11.015.

The Oxygen Paradox, oxidative stress, and ageing

Kelvin J A Davies  1
Affiliations

The Oxygen Paradox, oxidative stress, and ageing

Kelvin J A Davies. Arch Biochem Biophys. .

Abstract

Professor Helmut Sies is being lauded in this special issue of Archives of Biochemistry & Biophysics, on the occasion of his retirement as Editor-in-Chief. There is no doubt that Helmut has exerted an enormously positive influence on this journal, the fields of Biochemistry & Biophysics in general, and the areas of free radical and redox biology & medicine in particular. Helmut Sies' many discoveries about peroxide metabolism, glutathione, glutathione peroxidases, singlet oxygen, carotenoids in general and lycopene in particular, and flavonoids, fill the pages of his more than 600 publications. In addition, he will forever be remembered for coining the term 'oxidative stress' that is so widely used (and sometimes abused) by most of his colleagues.

Keywords: Ageing; Carotenoids, flavenols, and flavonoids; Glutathione and glutathione peroxidase; Oxidative stress; Peroxynitrite and nitric xide; Singlet oxygen.

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Figures

Fig. 1
Fig. 1
The author (right) and Professor Helmut Sies (left) at a meeting in November 1999. The author has clearly been impressed by a comment of Prof. Sies. Lester Packer can (just) be seen in the background.
Fig. 2
Fig. 2
Above we see Prof Enrique Cadenas (left), Helmut Sies, the author, and Prof. Giuseppe Poli (right) on October 3, 1996 in Barcelona, Spain, at the VIII Biennial Meeting of the International Society for Free Radical Research.
Fig. 3
Fig. 3
Prof. Helmut Sies with Prof. Christine Winterbourn on November 20 2014 in Seattle, Washington, USA, at the annual Editorial Board meeting of the journal Free Radical Biology & Medicine. Both Profs. Sies and Winterbourn were inducted as members of the FRBM Distinguished Editorial Board at the meeting.
See this image and copyright information in PMC

References

    1. Sies H. Oxidative stress: introductory remarks. In: Sies H, editor. Oxidative Stress. Academic Press; London: 1985. pp. 1–8.
    1. Sies H. Biochemistry of Oxidative Stress. Angew Chem Int Ed Engl. 1986;25:1058–1071.
    1. Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. The Journal of biological chemistry. 2014;289:8735–8741. - PMC - PubMed
    1. Sies H. Oxidative stress: a concept in redox biology and medicine. Redox biology. 2015;4c:180–183. - PMC - PubMed
    1. Davies KJA, Ursini F. The Oxygen Paradox. Cleup University Press; Padova, Italy: 1995. pp. 1–811.