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. 2016 Jun 21;7(25):38857-38863.
doi: 10.18632/oncotarget.8754.

Alcohol and survival in ESCC: prediagnosis alcohol consumption and postoperative survival in lymph node-negative esophageal carcinoma patients

Qilong Ma  1 , Wengao Liu  1 , Ran Jia  1 , Hao Long  1 , Lanjun Zhang  1 , Peng Lin  1 , Hongyun Zhao  1 , Guowei Ma  1
Affiliations

Alcohol and survival in ESCC: prediagnosis alcohol consumption and postoperative survival in lymph node-negative esophageal carcinoma patients

Qilong Ma et al. Oncotarget. .

Abstract

Background: The association between esophageal cancer and prediagnosis alcohol consumption is well established. However, evidence that prediagnosis alcohol consumption affects postoperative survival in patients with lymph node-negative esophageal squamous cell carcinoma (ESCC) is lacking. We conducted a retrospective study on the effect of prediagnosis alcohol consumption on the postoperative survival of patients with lymph node-negative ESCC in China.

Methods: We enrolled 643 ESCC patients with negative lymphatic metastasis who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China, and reviewed their demographic, pathologic, preoperative, and cancer outcome data obtained from medical records. These data were analyzed using life table and Kaplan-Meier analyses and multivariate Cox regression.

Results: There was a significant reduction in 3- and 5-year survival in drinkers with lymph node-negative ESCC. For drinkers, 3- and 5-year survival rates were 43% and 36% respectively, whereas, for nondrinkers, the corresponding values were 63% and 58%, respectively (p < 0.05). Multivariate Cox regression showed that drinking (p = 0.001, relative risk =1.583) was an independent factor for survival in patients with lymph node-negative ESCC. Striated analysis revealed that drinking was an independent factor for survival in patients with stage II A (p = 0.008, relative risk =1.679), stage IB (p = 0.044, relative risk=1.517), and well (p=0.011, relative risk =1.783) and moderately (p = 0.002, relative risk = 1.915) differentiated ESCC.

Conclusions: Prediagnosis alcohol consumption is an independent prognostic factor for postoperative survival in patients with lymph node-negative ESCC.

Keywords: Chinese cohort; alcohol consumption; esophageal carcinoma; postoperative survival.

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Conflict of interest statement

There is no conflict of interest.

Figures

Figure 1
Figure 1. Kaplan-Meier survival curve of patients grouped by drinking and nondrinking habit
Figure 2
Figure 2. Kaplan-Meier survival curve striated by postoperative staging of ESCC
Figure 3
Figure 3. Kaplan-Meier survival curve striated by grade of differentiation of ESCC
See this image and copyright information in PMC

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