Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Jun;24(6):427-429.
doi: 10.1016/j.tim.2016.04.001. Epub 2016 Apr 16.

Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential

Susanna K P Lau  1 , Patrick C Y Woo  2
Affiliations
Comment

Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential

Susanna K P Lau et al. Trends Microbiol. 2016 Jun.

Abstract

A recent study provides a platform for generating infectious coronavirus genomes using sequence data, examining their capabilities of replicating in human cells and causing diseases in animal models, and evaluating therapeutics and vaccines. Similar approaches could be used to assess the potential of human emergence and pathogenicity for other viruses.

PubMed Disclaimer

Comment on

  • SARS-like WIV1-CoV poised for human emergence.
    Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. Menachery VD, et al. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976607 Free PMC article.

References

    1. Menachery V.D. SARS-like WIV1-CoV poised for human emergence. Proc. Natl. Acad. Sci. U.S.A. 2016;113:3048–3053. - PMC - PubMed
    1. Menachery V.D. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat. Med. 2015;21:1508–1513. - PMC - PubMed
    1. Guan Y. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed
    1. Lau S.K. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl. Acad. Sci. U.S.A. 2005;102:14040–14045. - PMC - PubMed
    1. Li W. Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005;310:676–679. - PubMed

Publication types

LinkOut - more resources