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. 2016 Jul;12(13):1577-86.
doi: 10.2217/fon-2016-0083. Epub 2016 Apr 20.

Conformal radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma: is it safe?

Kayvan Mohkam  1   2 , Nicolas Golse  1 , Mathieu Bonal  1 , Stanislas Ledochowski  3 , Agnès Rode  4 , Imad E Selmaji  5 , Philippe Merle  6 , Christian Ducerf  1 , Françoise Mornex  2   5 , Jean-Yves Mabrut  1   2
Affiliations

Conformal radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma: is it safe?

Kayvan Mohkam et al. Future Oncol. 2016 Jul.

Abstract

Aim: To report a preliminary experience of conformal radiotherapy (CRT) as bridge to orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC).

Methods: Data of 12 patients undergoing CRT for HCC followed by OLT between 2012 and 2014 were reviewed.

Results: CRT was used in a neoadjuvant or downstaging setting in nine and three patients, respectively. No radiation-related systemic toxicity was observed. Median blood loss and operating time were 1450 ml (600-4000) and 420 min (240-510), respectively. Four patients had diaphragmatic injury. Complete histological response was observed in six patients, and partial response in five. Seven patients developed severe postoperative morbidity including five anastomosis-related complications and one death.

Conclusion: CRT for HCC provides satisfactory histological response but may compromise OLT safety.

Keywords: bridging therapy; conformal radiotherapy; hepatocellular carcinoma; morbidity; orthotopic liver transplantation.

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