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Comment
. 2016 Apr 19;44(4):713-5.
doi: 10.1016/j.immuni.2016.03.015.

Monocytes Take Their Own Path to IL-1β

Eric I Elliott  1 , Fayyaz S Sutterwala  2
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Free article
Comment

Monocytes Take Their Own Path to IL-1β

Eric I Elliott et al. Immunity. .
Free article

Abstract

Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus.

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  • Human Monocytes Engage an Alternative Inflammasome Pathway.
    Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V. Gaidt MM, et al. Immunity. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. Immunity. 2016. PMID: 27037191

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