Bugs and Brain: How Infection Makes You Feel Blue

Jasmin Herz¹, Jonathan Kipnis²

Affiliations

¹ Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: jh2vc@virginia.edu.
² Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kipnis@virginia.edu.

PMID: 27096312
DOI: 10.1016/j.immuni.2016.03.010

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Bugs and Brain: How Infection Makes You Feel Blue

Jasmin Herz et al. Immunity. 2016.

Free article

. 2016 Apr 19;44(4):718-20.

doi: 10.1016/j.immuni.2016.03.010.

Authors

Jasmin Herz¹, Jonathan Kipnis²

Affiliations

¹ Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: jh2vc@virginia.edu.
² Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kipnis@virginia.edu.

PMID: 27096312
DOI: 10.1016/j.immuni.2016.03.010

Abstract

In this issue of Immunity, Prinz and colleagues (2016) describe an unexpected mechanism underlying the role of type I interferon in the initiation of cognitive impairment and sickness behavior during viral infection through induction of chemokine CXCL10 in central nervous system epithelial and endothelial cells.

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Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.
Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Blank T, et al. Immunity. 2016 Apr 19;44(4):901-12. doi: 10.1016/j.immuni.2016.04.005. Immunity. 2016. PMID: 27096319

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Bugs and Brain: How Infection Makes You Feel Blue

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Bugs and Brain: How Infection Makes You Feel Blue

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