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. 2017 Sep;22(5):205-209.
doi: 10.1080/13510002.2016.1173328. Epub 2016 Apr 20.

Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis

Soner Sertan Kara  1 , Ozcan Erel  2 , Tugba Bedir Demirdag  1 , Burcu Ceylan Cura Yayla  1 , Belgin Gulhan  3 , Salim Neselioglu  2 , Meltem Polat  1 , Gokhan Kalkan  4 , Anil Tapisiz  1 , Hasan Tezer  1
Affiliations

Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis

Soner Sertan Kara et al. Redox Rep. 2017 Sep.

Abstract

Objective: Thiol-disulphide homeostasis (TDH) has a critical role in various clinical disorders. We aimed to assess the association of TDH with acute tonsillopharyngitis (AT) in children.

Methods: This study included 94 (73 viral and 21 bacterial) tonsillopharyngitis patients and 88 control children. Their native thiol, total thiol, and disulphide levels were measured.

Results: Viral and bacterial tonsillopharyngitis patients had lower native thiol levels compared with healthy children (P < 0.001 and P = 0.008, respectively). Both groups had lower total thiol levels compared with control children (P = 0.002 for viral, P = 0.011 for bacterial). The disulphide levels were lower in bacterial than in viral tonsillopharyngitis patients (P = 0.04), and there was a significant difference between viral tonsillopharyngitis patients and the control group (P < 0.001). The native/total thiol ratio in each patient group was lower than in the control group (P < 0.001 for viral, P = 0.017 for bacterial). The disulphide/native thiol and disulphide/total thiol ratios were significantly higher in viral (P < 0.001 for both) and bacterial tonsillopharyngitis patients (P = 0.017 for both) than in healthy children. In all patients, a correlation was found between the levels of C-reactive protein (CRP) and native thiol (r = -0.211, P = 0.04), CRP and total thiol (r = -0.217, P = 0.036), white blood cell (WBC) and native thiol (r = -0.228, P = 0.002), WBC and total thiol (r = -0.191, P = 0.01), and WBC and disulphide (r = 0.160, P = 0.03).

Discussion: TDH is altered in AT in children. The alteration is more prominent in viral than in bacterial tonsillopharyngitis.

Keywords: Acute tonsillopharyngitis; Children; Thiol-disulphide homeostasis.

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Conflict of interest statement

Conflict of interest There is no conflicts of interest.

Figures

Figure 1
Figure 1
Native thiol levels by infection type. Control children had higher native thiol values than both viral and bacterial tonsillopharyngitis patients.
Figure 2
Figure 2
Disulphide levels by infection type. Viral tonsillopharyngitis patients had higher serum disulphide levels than bacterial tonsillopharyngitis patients.
Figure 3
Figure 3
Disulphide/native thiol ratios by infection type. The disulphide/native thiol ratio was higher in the viral and bacterial tonsillopharyngitis patients than in the control children.
See this image and copyright information in PMC

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