A research roadmap for next-generation sequencing informatics

Russ B Altman¹, Snehit Prabhu², Arend Sidow³, Justin M Zook⁴, Rachel Goldfeder⁵, David Litwack⁶, Euan Ashley⁷, George Asimenos⁸, Carlos D Bustamante², Katherine Donigan⁶, Kathleen M Giacomini⁹, Elaine Johansen⁶, Natalia Khuri¹⁰, Eunice Lee⁶, Xueying Sharon Liang⁶, Marc Salit¹¹, Omar Serang⁸, Zivana Tezak⁶, Dennis P Wall¹², Elizabeth Mansfield⁶, Taha Kass-Hout⁶

Affiliations

¹ Bioengineering, Genetics, and Medicine, Stanford University, Stanford, CA 94305, USA. russ.altman@stanford.edu.
² Biomedical Data Science and Genetics, Stanford University, Stanford, CA 94305, USA.
³ Pathology and Genetics, Stanford University, Stanford, CA 94305, USA.
⁴ Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
⁵ Biomedical Informatics, Stanford University, Stanford, CA 94305, USA.
⁶ Food and Drug Administration, Silver Spring, MD 20993, USA.
⁷ Medicine, Genetics, and Pathology, Stanford University, Stanford, CA 94305, USA.
⁸ DNAnexus, Mountain View, CA 94040, USA.
⁹ Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143, USA.
¹⁰ Bioengineering, Stanford University, Stanford, CA 94305, USA.
¹¹ Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Bioengineering, Stanford University, Stanford, CA 94305, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
¹² Systems Medicine and Psychiatry, Stanford University, Stanford, CA 94305, USA.

PMID: 27099173
PMCID: PMC6233899
DOI: 10.1126/scitranslmed.aaf7314

Review

A research roadmap for next-generation sequencing informatics

Russ B Altman et al. Sci Transl Med. 2016.

. 2016 Apr 20;8(335):335ps10.

doi: 10.1126/scitranslmed.aaf7314.

Authors

Affiliations

¹ Bioengineering, Genetics, and Medicine, Stanford University, Stanford, CA 94305, USA. russ.altman@stanford.edu.
² Biomedical Data Science and Genetics, Stanford University, Stanford, CA 94305, USA.
³ Pathology and Genetics, Stanford University, Stanford, CA 94305, USA.
⁴ Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
⁵ Biomedical Informatics, Stanford University, Stanford, CA 94305, USA.
⁶ Food and Drug Administration, Silver Spring, MD 20993, USA.
⁷ Medicine, Genetics, and Pathology, Stanford University, Stanford, CA 94305, USA.
⁸ DNAnexus, Mountain View, CA 94040, USA.
⁹ Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143, USA.
¹⁰ Bioengineering, Stanford University, Stanford, CA 94305, USA.
¹¹ Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Bioengineering, Stanford University, Stanford, CA 94305, USA. Material Measurement Laboratory, National Institute of Standards and Technology, Stanford University, Stanford, CA 94305, USA.
¹² Systems Medicine and Psychiatry, Stanford University, Stanford, CA 94305, USA.

PMID: 27099173
PMCID: PMC6233899
DOI: 10.1126/scitranslmed.aaf7314

Abstract

Next-generation sequencing technologies are fueling a wave of new diagnostic tests. Progress on a key set of nine research challenge areas will help generate the knowledge required to advance effectively these diagnostics to the clinic.

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References

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A research roadmap for next-generation sequencing informatics

Affiliations

A research roadmap for next-generation sequencing informatics

Authors

Affiliations

Abstract

References

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MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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