Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 May 10;113(19):E2556-7.
doi: 10.1073/pnas.1600618113. Epub 2016 Apr 20.

Reply to Wang et al.: Sequencing datasets do not refute Central Asian domestication origin of dogs

Laura M Shannon  1 , Ryan H Boyko  2 , Marta Castelhano  3 , Elizabeth Corey  3 , Jessica J Hayward  1 , Corin McLean  4 , Michelle E White  1 , Mounir R Abi Said  5 , Baddley A Anita  6 , Nono Ikombe Bondjengo  7 , Jorge Calero  8 , Ana Galov  9 , Marius Hedimbi  10 , Bulu Imam  11 , Rajashree Khalap  12 , Douglas Lally  13 , Andrew Masta  14 , Kyle C Oliveira  1 , Lucía Pérez  15 , Julia Randall  16 , Nguyen Minh Tam  17 , Francisco J Trujillo-Cornejo  15 , Carlos Valeriano  8 , Nathan B Sutter  18 , Rory J Todhunter  3 , Carlos D Bustamante  19 , Adam R Boyko  20
Affiliations
Comment

Reply to Wang et al.: Sequencing datasets do not refute Central Asian domestication origin of dogs

Laura M Shannon et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: A.R.B. and R.H.B. are cofounders and officers of Embark Veterinary, Inc., a canine genetics testing company.

Figures

Fig. 1.
Fig. 1.
Decay of LD curves computed from variant calls from whole-genome sequencing [Auton et al. (5), dashed lines] and from Illumina array genotypes [Shannon et al. (2), solid lines]. For each population, the same six dogs were used for sequencing and genotyping, and curves are computed based on the 156,000 autosomal markers passing quality control in both datasets. Thus, differences in LD decay estimates for the same population are due solely to genotyping discordances between the sequenced and genotyped data.
Fig. 2.
Fig. 2.
Decay of LD in village dog populations based on six resequenced samples based on variant calls only at positions on the Illumina array. Mean depth of sequencing coverage is given in parentheses.
See this image and copyright information in PMC

Comment on

References

    1. Wang G-D, Peng M-S, Yang H-C, Savolainen P, Zhang Y-P. Questioning the evidence for a Central Asian domestication origin of dogs. Proc Natl Acad Sci USA. 2016;113:E2554–E2555. - PMC - PubMed
    1. Shannon LM, et al. Genetic structure in village dogs reveals a Central Asian domestication origin. Proc Natl Acad Sci USA. 2015;112(44):13639–13644. - PMC - PubMed
    1. Gou X, et al. Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia. Genome Res. 2014;24(8):1308–1315. - PMC - PubMed
    1. Cheng AY, Teo YY, Ong RT. Assessing single nucleotide variant detection and genotype calling on whole-genome sequenced individuals. Bioinformatics. 2014;30(12):1707–1713. - PubMed
    1. Auton A, et al. Genetic recombination is targeted towards gene promoter regions in dogs. PLoS Genet. 2013;9(12):e1003984. - PMC - PubMed

LinkOut - more resources