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Review
. 2016 Apr 21;22(15):3907-36.
doi: 10.3748/wjg.v22.i15.3907.

MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma

Sirio Fiorino  1 , Maria Letizia Bacchi-Reggiani  1 , Michela Visani  1 , Giorgia Acquaviva  1 , Adele Fornelli  1 , Michele Masetti  1 , Andrea Tura  1 , Fabio Grizzi  1 , Matteo Zanello  1 , Laura Mastrangelo  1 , Raffaele Lombardi  1 , Luca Di Tommaso  1 , Arrigo Bondi  1 , Sergio Sabbatani  1 , Andrea Domanico  1 , Carlo Fabbri  1 , Paolo Leandri  1 , Annalisa Pession  1 , Elio Jovine  1 , Dario de Biase  1
Affiliations
Review

MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma

Sirio Fiorino et al. World J Gastroenterol. .

Abstract

Aim of the present review is to summarize the current knowledge about the potential relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related liver diseases. A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine miRNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma (HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: "HBV", "HCV", "hepatocellular carcinoma", "microRNAs", "miRNAs", "diagnosis", "prognosis", "therapy", "treatment". Some serum/plasma miRNAs, including miR-21, miR-122, mi-125a/b, miR-199a/b, miR-221, miR-222, miR-223, miR-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of miRNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of miRNAs for HCC early detection and prognosis.

Keywords: Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinomas; Liver diseases; MicroRNAs; Review.

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