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Case Reports
. 2016 Mar 29:12:695-7.
doi: 10.2147/NDT.S103687. eCollection 2016.

Neuroleptic malignant syndrome and subsequent clozapine-withdrawal effects in a patient with refractory schizophrenia

Minfeng Cheng  1 , Huaying Gu  1 , Liangrong Zheng  1 , Houliang Wang  1 , Zhiyong Zhong  1 , Shenglin Wen  1
Affiliations
Case Reports

Neuroleptic malignant syndrome and subsequent clozapine-withdrawal effects in a patient with refractory schizophrenia

Minfeng Cheng et al. Neuropsychiatr Dis Treat. .

Abstract

Here, we report a female patient developing neuroleptic malignant syndrome following the use of a combination of clozapine and haloperidol. Subsequently, the patient presented withdrawal effects after an abrupt discontinuation of clozapine. Psychiatrists not aware of possible clozapine-withdrawal effects may misdiagnose as a part of the primary mental illness or as the initial symptoms worsening, if unrecognized.

Keywords: clozapine; neuroleptic malignant syndrome; schizophrenia; withdrawal effect.

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