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Review
. 2016 Spring;9(2):78-86.

Survival rate of gastric cancer in Iran; a systematic review and meta-analysis

Yousef Veisani  1 , Ali Delpisheh  2
Affiliations
Review

Survival rate of gastric cancer in Iran; a systematic review and meta-analysis

Yousef Veisani et al. Gastroenterol Hepatol Bed Bench. 2016 Spring.

Abstract

Aim: In this study, we aimed to estimate one- to five-year survival rates in Iranian patients with gastric cancer (GC). In addition, we preformed subgroup analyses and meta-regression to explore possible sources of heterogeneity between studies.

Background: According to literatures, there has been increasing attention to the long-term survival rate in patients with GC in Iran. However, results have been inconsistent and remain controversial in overall survival rates.

Patients and methods: Literature searches were conducted using PubMed, Scopus, and ISI, as well as Magiran, Medlib, SID, and Iran Medex databases. Studies were pooled and summary one to five survival rates were calculated. Univariate and multivariate regression analyses were used to explore possible sources of heterogeneity among studies. Subgroup analyses were also conducted. Analyses were conducted using the STATA statistical software package.

Results: Final analysis of 29361 patients from 26 eligible studies was performed. The overall survival rate (one to five years) in all studies, by meta-analysis of 24, 14, 23, 12 and 22 studies were 52%, 31%, 24%, 22%, and 15%, respectively. Meta-regression analysis showed an increase in one- and five-year survival rate over the time (Reg Coef = 0.016, p= 0.04) and (Reg Coef= 0.021, p= 0.049), respectively. Positive heterogeneity was observed between quality of papers and data sources (P<0.001).

Conclusion: More than half of GC deaths happened in the first year at diagnosis, and another 30% plus they occurred during the second year after confirmed diagnosis. Our results admit lower survival rates in Iran, similar to other developing countries.

Keywords: Gastric cancer; Heterogeneityndrial; Meta-analysis; Survival rate; Systematic review.

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Figures

Figure 1
Figure 1
Flow diagram shows different steps involved in searching for relevant publications (2005–2015
Figure 3
Figure 3
Meta-analysis of the five year survival rate by different data source (Hospital Records and Cancer Registry Centers)
Figure 4
Figure 4
Meta-regression plots of change in one and five survival rate according to changes in continuous study moderator’s year
See this image and copyright information in PMC

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