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. 2016 Jan-Mar;8(1):48-57.

Phage Peptide Libraries As a Source of Targeted Ligands

A A Nemudraya  1 , V A Richter  1 , E V Kuligina  1
Affiliations

Phage Peptide Libraries As a Source of Targeted Ligands

A A Nemudraya et al. Acta Naturae. 2016 Jan-Mar.

Abstract

One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in relation to oncologic diseases. Short tissue- and organ-specific peptides capable of delivering drugs to the affected organ or tissue are considered promising targeted agents that can be used in the diagnosis and therapy of diseases, including cancer. The review discusses in detail the technology of phage display as a method for obtaining specific targeted peptide agents and offers examples of their use in diagnostic and clinical practice.

Keywords: drug delivery; phage display; phage peptide libraries; targeted peptides.

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Figures

Fig. 1
Fig. 1
The structure of a bacteriophage with a displayed foreign amino acid sequence in a pIII surface protein (indicated in red). N1, N2 and C – domains of the pIII surface protein
Fig. 2
Fig. 2
Schematic representation of a typical biopanning of a phage library. A, B – incubation of a combinatorial phage library with a target; C – washing-off of the unbound phages; D – elution of bound phages and their amplification for the next rounds
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