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. 2016 Jun 1;55(23):6730-3.
doi: 10.1002/anie.201601206. Epub 2016 Apr 21.

Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Mikhail O Konev  1 , Luke E Hanna  1 , Elizabeth R Jarvo  2
Affiliations

Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Mikhail O Konev et al. Angew Chem Int Ed Engl. .

Abstract

Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.

Keywords: cross-coupling; cyclization; heterocycles; nickel; zinc.

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