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. 2016 May 26;7(3):75-83.
doi: 10.1080/21541264.2016.1181142. Epub 2016 Apr 21.

A critical role for topoisomerase IIb and DNA double strand breaks in transcription

Stuart K Calderwood  1
Affiliations

A critical role for topoisomerase IIb and DNA double strand breaks in transcription

Stuart K Calderwood. Transcription. .

Abstract

Recent studies have indicated a novel role for topoisomerase IIb in transcription. Transcription of heat shock genes, serum-induced immediate early genes and nuclear receptor-activated genes, each required DNA double strands generated by topoisomerase IIb. Such strand breaks seemed both necessary and sufficient for transcriptional activation. In addition, such transcription was associated with initiation of the DNA damage response pathways, including the activation of the enzymes: ataxia-telangiectasia mutated (ATM), DNA-dependent protein kinase and poly (ADP ribose) polymerase 1. DNA damage response signaling was involved both in transcription and in repair of DNA breaks generated by topoisomerase IIb.

Keywords: ATM; DNA-PK; PARP1; PIKK kinase; strand break; topoisomerase II; transcripton.

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Figures

Figure 1.
Figure 1.
Role of Topoisomerase IIb in Transcription.
Figure 2.
Figure 2.
PIKK Kinases and DNA Damage.
Figure 3.
Figure 3.
Combinatorial Roles of Topoisomerase IIb, PARP1 and PIKK kinases in Transcription.
See this image and copyright information in PMC

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