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. 2016 Jun 21;7(25):38864-38875.
doi: 10.18632/oncotarget.8778.

Prognosis of subtypes of the mucinous breast carcinoma in Chinese women: a population-based study of 32-year experience (1983-2014)

Bo Pan  1 , Ru Yao  1 , Jie Shi  2 , Qian-Qian Xu  1 , Yi-Dong Zhou  1 , Feng Mao  1 , Yan Lin  1 , Jing-Hong Guan  1 , Xue-Jing Wang  1 , Yan-Na Zhang  1 , Xiao-Hui Zhang  1 , Song-Jie Shen  1 , Ying Zhong  1 , Ya-Li Xu  1 , Qing-Li Zhu  3 , Zhi-Yong Liang  2 , Qiang Sun  1
Affiliations

Prognosis of subtypes of the mucinous breast carcinoma in Chinese women: a population-based study of 32-year experience (1983-2014)

Bo Pan et al. Oncotarget. .

Abstract

Purpose: The heterogeneous nature of the mucinous breast cancer (MBC), with its pure (PMBC) and mixed subtypes (MMBC), calls for precise prognosis assessment.

Methods: We analyzed 197 consecutive MBC patients, including 117 PMBC and 80 MMBC, who were treated from 1983 to 2014. The clinicopathological features, treatment choice, disease-free survival (DFS) and overall survival (OS) were compared among PMBC, MMBC and MMBC subgroups. Prognostic factors of PMBC and MMBC were identified.

Results: Compared to PMBC, MMBC had more lymph node metastasis (p = 0.043), Her2 positivity (p = 0.036), high Ki-67 index (defined as>20%, p = 0.026) and anti-Her2 targeted therapy (p = 0.016). The 5-year DFS of PMBC and MMBC were 90.4% and 86.2%, whereas the 5-year OS were 99.0% and 98.7%. No significant difference was found in DFS or OS among all MBC subtypes. High Ki-67 (p = 0.020) appeared as DFS factor in PMBC, while anti-Her2 targeted therapy (p = 0.047) as the DFS predictors in MMBC.

Conclusion: MMBC manifested similar 5-year survival to PMBC in Chinese woman, suggesting that intra-tumoral heterogeneity might not interfere with MBC short-term prognosis.

Keywords: mucinous breast cancer; prognosis; subtype.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Diagram of the research design
The clinic-pathological characteristics and the survival outcomes (DFS and OS) were firstly compared between PMBC and MMBC, and then between PMBC, MBC+DCIS+IDC, MBC+IDC and MBC+IMPC. Two patients with MBC+ILC were excluded from the second comparison due to limited case number. Abbreviations: MBC, mucinous breast cancer; PMBC, pure mucinous breast cancer; MMBC, mixed mucinous breast cancer; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; IMPC, invasive micropapillary carcinoma; DFS, disease free survival; OS, overall survival.
Figure 2
Figure 2. Kaplan-Meier estimates of DFS and OS of MBC patients
DFS A. and OS B. compared between PMBC and MMBC patients. The comparison of DFS C. and OS D. of PMBC, MBC+DCIS+IDC, MBC+IDC, and MBC+IMPC patients. DFS of PMBC patients compared between subgroups of Ki-67 high (defined as ≥ 20%) versus Ki-67 low (defined as < 20%) E. DFS of MMBC patients compared between patient subgroups with or without anti-Her2 targeted therapy F..
See this image and copyright information in PMC

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