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. 1977 Dec 10;2(6101):1511-2.
doi: 10.1136/bmj.2.6101.1511.

Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia

A W Craft, H Kay, D N Lawson, T J McElwain

Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia

A W Craft et al. Br Med J. .

Abstract

A one-hour D-xylose absorption test was performed on 18 children with acute lymphoblastic leukaemia. Xylose absorption was normal in children who had not received methotrexate, but there was a significant degree of malabsorption in those who had taken methotrexate within the previous seven days. There was a progressive and significant increase in malabsorption related to the cumulative dose of methotrexate. These findings provide further evidence that regular methotrexate treatment every seven days is more toxic than if it is more widely spaced. The spacing of treatment is currently under investigation.

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References

    1. Am J Dig Dis. 1959 Sep;4:700-5 - PubMed
    1. Cancer Treat Rev. 1976 Mar;3(1):17-41 - PubMed
    1. Lancet. 1973 Nov 10;2(7837):1043-5 - PubMed
    1. N Engl J Med. 1972 Oct 12;287(15):769-77 - PubMed
    1. Arch Dis Child. 1976 Jul;51(7):489-93 - PubMed

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