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. 2016 Apr 5:12:527-33.
doi: 10.2147/TCRM.S99224. eCollection 2016.

Clinical effects and safety of treating diabetic macular edema with intravitreal injection of ranibizumab combined with retinal photocoagulation

Panshi Yan  1 , Cheng Qian  1 , Wenzhan Wang  1 , Yi Dong  1 , Guangming Wan  1 , Yue Chen  1
Affiliations

Clinical effects and safety of treating diabetic macular edema with intravitreal injection of ranibizumab combined with retinal photocoagulation

Panshi Yan et al. Ther Clin Risk Manag. .

Abstract

Background: This study was designed to examine the clinical effects of treating diabetic macular edema with an intravitreal injection of ranibizumab in combination with retinal photocoagulation.

Methods: Sixty-two cases (75 eyes) with confirmed severe proliferative diabetic retinopathy or proliferative diabetic retinopathy in combination with macular edema were randomly divided into the observation group (37 eyes were given an intravitreal injection of ranibizumab combined with retinal photocoagulation) and the control group (38 eyes received retinal photocoagulation only). Vision, fundus condition, central macular thickness, and the macular leakage area were recorded before and after treatment.

Results: The best-corrected visual acuity and macular leakage area were similar between the observation and control groups (P>0.05). The best-corrected visual acuity in the observation group was higher than that in the control group 3 and 6 months after treatment (P<0.05) and showed a rising tendency. The macular leakage area in the observation group was significantly lower than that in the control group 1 and 3 months after treatment (P<0.05). However, the macular leakage area was similar 6 months after treatment (P>0.05). The central macular thickness of the observation group was lower than that in the control group 1, 3, and 6 months after treatment (P<0.05). The laser energy used in the observation group was also smaller than that in the control group (P<0.05). The intraocular pressure was not significantly different between the groups (P<0.05). No patients in the two groups developed eye or systemic complications, such as glaucoma, cataract, or vitreous hemorrhage during treatment.

Conclusion: Intravitreal injection of ranibizumab combined with retinal photocoagulation was proven to be effective in treating diabetic macular edema as it improved vision and resulted in fewer complications.

Keywords: diabetic macular edema; photocoagulation; ranibizumab; vitreous body.

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Figures

Figure 1
Figure 1
Changes of vision in the observation group and the control group at different time points.
Figure 2
Figure 2
Changes of leakage area of RNV in the observation group and the control group at different time points.
Figure 3
Figure 3
Changes of CMT in the observation group at different time points (μm). Abbreviation: CMT, central macular edema.
Figure 4
Figure 4
Changes of CMT in the observation group and the control group. Notes: A is before combined treatment; B, is after one month after retinal photocoagulation; C is six months after retinal photocoagulation; D is after one month combined treatment; and E is six months after combined treatment. Abbreviation: CMT, central macular edema.
See this image and copyright information in PMC

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