Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;10(2):V-VIII.

Intake of Pomegranate Prevents the Onset of Osteoarthritis: Molecular Evidences

Intake of Pomegranate Prevents the Onset of Osteoarthritis: Molecular Evidences

Zafar Rasheed. Int J Health Sci (Qassim). 2016 Apr.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Pomegranate fruit extract (PEF) induced silencing of OA relevant genes via inhibition of IL-1β-induced signaling cascade in human OA chondrocytes
Solid lines indicate activation, breaking lines indicate expected activation, p in blue circles indicates phosphorylation, and PFE targets are shown in red.

References

    1. Greene MA, Loeser RF. Aging-related inflammation in osteoarthritis. Osteoarthritis Cartilage. 2015;23:1966–71. - PMC - PubMed
    1. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33–42. - PubMed
    1. Alghasham A, Rasheed Z. Therapeutic targets for rheumatoid arthritis: Progress and promises. Autoimmunity. 2014;47:77–94. - PubMed
    1. Saklatvala J. Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets. 2007;8:305–13. - PubMed
    1. Rasheed Z, Haqqi TM. Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes. Biochim Biophys Acta. 2012;1823:2179–89. - PMC - PubMed

LinkOut - more resources