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. 2016 Nov 1;73(3):282-286.
doi: 10.1097/QAI.0000000000001037.

Brief Report: Seroprevalence of Pertussis Infection in HIV-Infected Adults in the United States

Stephanie B Troy  1 , Alexandria E-B Rossheim, DaShaunda D Hilliard, Tina D Cunningham
Affiliations

Brief Report: Seroprevalence of Pertussis Infection in HIV-Infected Adults in the United States

Stephanie B Troy et al. J Acquir Immune Defic Syndr. .

Abstract

Pertussis is a resurgent infection that can cause significant morbidity among adults. CD4 T cells are necessary for its clearance, but pertussis studies in HIV-infected adults are limited to case reports. We analyzed stored serum samples from 299 HIV-infected adults to determine the seroprevalence of pertussis among this population. We found that 4.3% of subjects had serologic evidence of recent pertussis infection, and annual incidence of pertussis infection among subjects not vaccinated against pertussis in the last 5 years was 10.5%-17.5%. Prospective studies are needed to define the clinical presentation of pertussis in HIV-infected adults and to optimize vaccination strategies.

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Conflict of interest statement

Authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Anti-Pertussis Toxin (PT) IgG Levels by Time since Pertussis Vaccination with Tdap The cumulative percentage of subjects with anti-PT IgG at certain levels or below among all 299 subjects included in the study.
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