Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Apr 21;62(2):153-155.
doi: 10.1016/j.molcel.2016.04.008.

An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection

Konstantinos Boulias  1 , Judy Lieberman  2 , Eric Lieberman Greer  3
Affiliations
Comment

An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection

Konstantinos Boulias et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, Gross et al. (2016) find a CpG DNA methylation signature in blood cells of patients with chronic well-controlled HIV infection that correlates with accelerated aging.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Treated HIV infected individuals’ display accelerated aging as assessed by 5mC patterns
5-methyl cytosine DNA methylation levels across the genome are used to create an epigenetic clock to assess individuals’ age. Blood DNA methylomes of HIV infected HAART treated individuals reveals a ~5 year acceleration of aging.
See this image and copyright information in PMC

Comment on

References

    1. Baquer NZ, Taha A, Kumar P, McLean P, Cowsik SM, Kale RK, Singh R, Sharma D. Biogerontology. 2009;10:377–413. - PubMed
    1. Benayoun BA, Pollina EA, Brunet A. Nature Rev Mol Cell Biol. 2015;16:593–610. - PMC - PubMed
    1. Deeks SG. Annu Rev Med. 2011;62:141–155. - PMC - PubMed
    1. Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, et al. Science. 2007;317:944–947. - PMC - PubMed
    1. Gross AM, Jaeger PA, Kreisberg JF, Licon K, Jepsen KL, Khosroheidari M, Morsey BM, Shen H, Flagg K, Chen D, et al. Mol Cell 2016 - PMC - PubMed