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Review
. 2016 Dec;34(12):1657-1665.
doi: 10.1007/s00345-016-1828-0. Epub 2016 Apr 22.

Follow-up after focal therapy in renal masses: an international multidisciplinary Delphi consensus project

P J Zondervan  1 , P G K Wagstaff  2 , M M Desai  3 , D M de Bruin  2   4 , A F Fraga  5 , B A Hadaschik  6 , J Köllermann  7 , U B Liehr  8 , S A Pahernik  6 , H P Schlemmer  8 , J J Wendler  9 , F Algaba  10 , J J M C H de la Rosette  2 , M P Laguna Pes  2
Affiliations
Review

Follow-up after focal therapy in renal masses: an international multidisciplinary Delphi consensus project

P J Zondervan et al. World J Urol. 2016 Dec.

Abstract

Purpose: To establish consensus on follow-up (FU) after focal therapy (FT) in renal masses. To formulate recommendations to aid in clinical practice and research.

Methods: Key topics and questions for consensus were identified from a systematic literature research. A Web-based questionnaire was distributed among participants selected based on their contribution to the literature and/or known expertise. Three rounds according to the Delphi method were performed online. Final discussion was conducted during the "8th International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer" among an international multidisciplinary expert panel.

Results: Sixty-two participants completed all three rounds of the online questionnaire. The panel recommended a minimum follow-up of 5 years, preferably extended to 10 years. The first FU was recommended at 3 months, with at least two imaging studies in the first year. Imaging was recommended biannually during the second year and annually thereafter. The panel recommended FU by means of CT scan with slice thickness ≤3 mm (at least three phases with excretory phase if suspicion of collecting system involvement) or mpMRI. Annual checkup for pulmonary metastasis by CT thorax was advised. Outside study protocols, biopsy during follow-up should only be performed in case of suspicion of residual/persistent disease or radiological recurrence.

Conclusions: The consensus led to clear FU recommendations after FT of renal masses supported by a multidisciplinary expert panel. In spite of the low level of evidence, these recommendations can guide clinicians and create uniformity in the follow-up practice and for clinical research purposes.

Keywords: Consensus; Delphi method; Focal therapy; Follow-up; Renal masses.

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Conflict of interest statement

All authors of this manuscript declare no conflict of interest. Ethical standards All human studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Figures

Fig. 1
Fig. 1
Composite figure of questions from the Delphi survey
See this image and copyright information in PMC

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