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. 2016 Jul;23(4):791-5.
doi: 10.1093/jamia/ocv213. Epub 2016 Apr 23.

An informatics research agenda to support precision medicine: seven key areas

Jessica D Tenenbaum  1 , Paul Avillach  2 , Marge Benham-Hutchins  3 , Matthew K Breitenstein  4 , Erin L Crowgey  5 , Mark A Hoffman  6 , Xia Jiang  7 , Subha Madhavan  8 , John E Mattison  9 , Radhakrishnan Nagarajan  10 , Bisakha Ray  11 , Dmitriy Shin  12 , Shyam Visweswaran  13 , Zhongming Zhao  14 , Robert R Freimuth  4
Affiliations

An informatics research agenda to support precision medicine: seven key areas

Jessica D Tenenbaum et al. J Am Med Inform Assoc. 2016 Jul.

Abstract

The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue to evolve and datasets grow in magnitude, a strong computational infrastructure will be essential to realize PM's vision of improved healthcare derived from personal data. In addition, informatics research and innovation affords a tremendous opportunity to drive the science underlying PM. The informatics community must lead the development of technologies and methodologies that will increase the discovery and application of biomedical knowledge through close collaboration between researchers, clinicians, and patients. This perspective highlights seven key areas that are in need of further informatics research and innovation to support the realization of PM.

Keywords: biomarkers; data sharing; informatics; precision medicine.

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Figures

Figure 1:
Figure 1:
Informatics methodology enables precision medicine (PM) throughout the Learning Healthcare System cycle. Patients – past, present, and future – are at the beginning and end of the cycle. Both healthcare and research participation result in the generation of data. Informatics methods and tools help turn data into information, and information into knowledge. That knowledge, in turn, influences individuals’ behavior and informs patient care. Informatics plays a key role in enabling each stage and transition of this cycle.
See this image and copyright information in PMC

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