Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2016 Apr 23;16(1):58.
doi: 10.1186/s12890-016-0213-5.

Lung functions among patients with pulmonary tuberculosis in Dar es Salaam - a cross-sectional study

Mohamed Manji  1 , Grace Shayo  2 , Simon Mamuya  3 , Rose Mpembeni  4 , Ahmed Jusabani  5 , Ferdinand Mugusi  2
Affiliations
Multicenter Study

Lung functions among patients with pulmonary tuberculosis in Dar es Salaam - a cross-sectional study

Mohamed Manji et al. BMC Pulm Med. .

Abstract

Background: Approximately 40-60 % of patients remain sufferers of sequela of obstructive, restrictive or mixed patterns of lung disease despite treatment for pulmonary tuberculosis (PTB). The prevalence of these abnormalities in Tanzania remains unknown.

Methods: A descriptive cross-sectional study was carried out among 501 patients with PTB who had completed at least 20 weeks of treatment. These underwent spirometry and their lung functions were classified as normal or abnormal (obstructive, restrictive or mixed). Logistic regression models were used to explore factors associated with abnormal lung functions.

Results: Abnormal lung functions were present in 371 (74 %) patients. There were 210 (42 %) patients with obstructive, 65 (13 %) patients with restrictive and 96 (19 %) patients with mixed patterns respectively. Significant factors associated with abnormal lung functions included recurrent PTB (Adj OR 2.8, CI 1.274 - 6.106), Human Immunodeficiency Virus (HIV) negative status (Adj OR 1.7, CI 1.055 - 2.583), age more than 40 years (Adj OR 1.7, CI 1.080 - 2.804) and male sex (Adj OR 1.7, CI 1.123 - 2.614).

Conclusion: The prevalence of abnormal lung functions is high and it is associated with male sex, age older than 40 years, recurrent PTB and HIV negative status.

Keywords: Obstruction; Restriction; Spirometry; TB sequlae.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow diagram for recruitment into the study
Fig. 2
Fig. 2
Prevalence and severity of abnormal lung functions. Pie charts showing the prevalence of the different types of lung function abnormalities (large pie chart, N = 501). The smaller pie charts show the severity of patients who had restrictive (small upper, n = 65) and obstructive abnormalities (small lower, n = 210)
See this image and copyright information in PMC

References

    1. WHO. The Global Burden of Disease 2004 Update. WHO. 2008.
    1. Miller TL, McNabb SJN, Hilsenrath P, Pasipanodya J, Weis SE. Personal and societal health quality lost to tuberculosis. PLoS One. 2009;4:e5080. doi: 10.1371/journal.pone.0005080. - DOI - PMC - PubMed
    1. Snider G, Doctor L, Demas T, Shaw A. Obstructive airway disease in patients with treated pulmonary tuberculosis. Am Rev Respir Dis. 1971;103(5):625–40. - PubMed
    1. Birath G, Caro J, Malmberg R, Simonsson BG. Airways obstruction in pulmonary tuberculosis. Scand J Respir Dis. 1966;47:27–36. - PubMed
    1. Lancaster JF, Tomashefski JF. Tuberculosis--a cause of emphysema. Am Rev Respir Dis. 1963;87:435–7. doi: 10.1164/arrd.1963.87.3P1.435. - DOI - PubMed

Publication types

LinkOut - more resources