A harmonized guidance is needed on how to "properly" frame review questions to make the best use of all available evidence in the assessment of effectiveness of complex interventions

Affiliations

¹ Department of Social Policy and Intervention, Centre for Evidence-Based Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford OX1 2ER, UK. Electronic address: ani.movsisyan@spi.ox.ac.uk.
² Warwick Evidence, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL.
³ Department of Social Policy and Intervention, Centre for Evidence-Based Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford OX1 2ER, UK.

Comment

Ani Movsisyan et al. J Clin Epidemiol. 2016 Sep.

. 2016 Sep:77:139-141.

doi: 10.1016/j.jclinepi.2016.04.003. Epub 2016 Apr 21.

¹ Department of Social Policy and Intervention, Centre for Evidence-Based Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford OX1 2ER, UK. Electronic address: ani.movsisyan@spi.ox.ac.uk.
² Warwick Evidence, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL.
³ Department of Social Policy and Intervention, Centre for Evidence-Based Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford OX1 2ER, UK.

No abstract available

Comment on

Users identified challenges in applying GRADE to complex interventions and suggested an extension to GRADE.
Movsisyan A, Melendez-Torres GJ, Montgomery P. Movsisyan A, et al. J Clin Epidemiol. 2016 Feb;70:191-9. doi: 10.1016/j.jclinepi.2015.09.010. Epub 2015 Sep 18. J Clin Epidemiol. 2016. PMID: 26388040
Applying GRADE to studies of complex interventions is possible but requires proper framing of the question.
Murad MH. Murad MH. J Clin Epidemiol. 2016 Sep;77:138-139. doi: 10.1016/j.jclinepi.2016.02.033. Epub 2016 Apr 21. J Clin Epidemiol. 2016. PMID: 27107881 No abstract available.