Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr 25;20(1):108.
doi: 10.1186/s13054-016-1273-x.

The LUNG SAFE: a biased presentation of the prevalence of ARDS!

Jesús Villar  1   2 , Marcus J Schultz  3 , Robert M Kacmarek  4   5
Affiliations

The LUNG SAFE: a biased presentation of the prevalence of ARDS!

Jesús Villar et al. Crit Care. .

Abstract

The recent Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) challenges current data on the prevalence of acute respiratory distress syndrome (ARDS). The LUNG SAFE investigators claimed that their data demonstrated the predictive validity of the Berlin criteria. Also, the LUNG SAFE showed a disturbingly large gap between scientific evidence and medical practice. All of these statements demand that we question the interpretations of the study's findings.

PubMed Disclaimer

Comment in

References

    1. The ARDS Network Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301–8. doi: 10.1056/NEJM200005043421801. - DOI - PubMed
    1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319–23. doi: 10.1016/S0140-6736(67)90168-7. - DOI - PubMed
    1. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. The American–European Consensus Conference on ARDS. Am J Respir Crit Care Med. 1994;149:818–24. doi: 10.1164/ajrccm.149.3.7509706. - DOI - PubMed
    1. The ARDS Definition Task Force Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012;307:2526–33. - PubMed
    1. Villar J, Pérez-Méndez L, Kacmarek RM. Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome. Intensive Care Med. 1999;25:930–5. doi: 10.1007/s001340050984. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources