HIV-Positive-to-HIV-Positive Liver Transplantation

A Calmy¹, C van Delden², E Giostra³, C Junet⁴, L Rubbia Brandt⁵, S Yerly⁶, J-P Chave⁷, C Samer⁸, L Elkrief³, J Vionnet⁹, T Berney³; Swiss HIV and Swiss Transplant Cohort Studies

Collaborators, Affiliations

Collaborators

Swiss HIV and Swiss Transplant Cohort Studies:
V Aubert, M Battegay, E Bernasconi, J Böni, H C Bucher, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, M Rickenbach, C Rudin, F Schöni-Affolter, P Schmid, J Schüpbach, R Speck, P Tarr, A Telenti, A Trkola, P Vernazza, R Weber, R Achermann, P Amico, J-D Aubert, P Baumann, G Beldi, C Benden, C Berger, I Binet, P-Y Bochud, E Boely, H Bucher, L Bühler, T Carell, E Catana, Y Chalandon, S de Geest, O de Rougemont, M Dickenmann, M Duchosal, T Fehr, S Ferrari-Lacraz, C Garzoni, P Gasche Soccal, D Golshayan, D Good, K Hadaya, J Halter, D Heim, C Hess, S Hillinger, H H Hirsch, G Hofbauer, U Huynh-Do, F Immer, R Klaghofer, M Koller, B Laesser, R Lehmann, C Lovis, O Manuel, H-P Marti, P Y Martin, L Martinolli, P Meylan, P Mohacsi, I Morard, P Morel, U Mueller, N J Mueller, H Mueller-McKenna, A Müller, T Müller, B Müllhaupt, D Nadal, M Pascual, J Passweg, C Piot Ziegler, J Rick, E Roosnek, A Rosselet, S Rothlin, F Ruschitzka, U Schanz, S Schaub, C Seiler, S Stampf, J Steiger, G Stirnimann, C Toso, D Tsinalis, J-P Venetz, J Villard, M Wick, M Wilhelm

Affiliations

¹ HIV Unit, Geneva University Hospitals, Geneva, Switzerland.
² Transplant Infectious Diseases Unit, Geneva University Hospitals, Geneva, Switzerland.
³ Division of Transplantation, Geneva University Hospitals, Geneva, Switzerland.
⁴ Private Practice, Geneva, Switzerland.
⁵ Division of Pathology, Geneva University Hospitals, Geneva, Switzerland.
⁶ Virology Laboratory, Geneva University Hospitals, Geneva, Switzerland.
⁷ Private Practice, Lausanne, Switzerland.
⁸ Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.
⁹ Division of Gastroenterology and Division of Transplantation, CHUV, Lausanne, Switzerland.

PMID: 27109874
DOI: 10.1111/ajt.13824

Free article

Case Reports

HIV-Positive-to-HIV-Positive Liver Transplantation

A Calmy et al. Am J Transplant. 2016 Aug.

Free article

. 2016 Aug;16(8):2473-8.

doi: 10.1111/ajt.13824. Epub 2016 Jun 7.

Authors

A Calmy¹, C van Delden², E Giostra³, C Junet⁴, L Rubbia Brandt⁵, S Yerly⁶, J-P Chave⁷, C Samer⁸, L Elkrief³, J Vionnet⁹, T Berney³; Swiss HIV and Swiss Transplant Cohort Studies

Collaborators

Swiss HIV and Swiss Transplant Cohort Studies:
V Aubert, M Battegay, E Bernasconi, J Böni, H C Bucher, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, M Rickenbach, C Rudin, F Schöni-Affolter, P Schmid, J Schüpbach, R Speck, P Tarr, A Telenti, A Trkola, P Vernazza, R Weber, R Achermann, P Amico, J-D Aubert, P Baumann, G Beldi, C Benden, C Berger, I Binet, P-Y Bochud, E Boely, H Bucher, L Bühler, T Carell, E Catana, Y Chalandon, S de Geest, O de Rougemont, M Dickenmann, M Duchosal, T Fehr, S Ferrari-Lacraz, C Garzoni, P Gasche Soccal, D Golshayan, D Good, K Hadaya, J Halter, D Heim, C Hess, S Hillinger, H H Hirsch, G Hofbauer, U Huynh-Do, F Immer, R Klaghofer, M Koller, B Laesser, R Lehmann, C Lovis, O Manuel, H-P Marti, P Y Martin, L Martinolli, P Meylan, P Mohacsi, I Morard, P Morel, U Mueller, N J Mueller, H Mueller-McKenna, A Müller, T Müller, B Müllhaupt, D Nadal, M Pascual, J Passweg, C Piot Ziegler, J Rick, E Roosnek, A Rosselet, S Rothlin, F Ruschitzka, U Schanz, S Schaub, C Seiler, S Stampf, J Steiger, G Stirnimann, C Toso, D Tsinalis, J-P Venetz, J Villard, M Wick, M Wilhelm

Affiliations

¹ HIV Unit, Geneva University Hospitals, Geneva, Switzerland.
² Transplant Infectious Diseases Unit, Geneva University Hospitals, Geneva, Switzerland.
³ Division of Transplantation, Geneva University Hospitals, Geneva, Switzerland.
⁴ Private Practice, Geneva, Switzerland.
⁵ Division of Pathology, Geneva University Hospitals, Geneva, Switzerland.
⁶ Virology Laboratory, Geneva University Hospitals, Geneva, Switzerland.
⁷ Private Practice, Lausanne, Switzerland.
⁸ Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland.
⁹ Division of Gastroenterology and Division of Transplantation, CHUV, Lausanne, Switzerland.

PMID: 27109874
DOI: 10.1111/ajt.13824

Abstract

Most countries exclude human immunodeficiency virus (HIV)-positive patients from organ donation because of concerns regarding donor-derived HIV transmission. The Swiss Federal Act on Transplantation has allowed organ transplantation between HIV-positive donors and recipients since 2007. We report the successful liver transplantation from an HIV-positive donor to an HIV-positive recipient. Both donor and recipient had been treated for many years with antiretroviral therapy and harbored multidrug-resistant viruses. Five months after transplantation, HIV viremia remains undetectable. This observation supports the inclusion of appropriate HIV-positive donors for transplants specifically allocated to HIV-positive recipients.

Keywords: clinical research/practice; ethics and public policy; immune deficiency; infectious disease; patient safety.

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Comment in

Advancing Transplant Care in AIDS: Encouraging Innovation in Transplantation.
Fishman JA, Feng S. Fishman JA, et al. Am J Transplant. 2016 Aug;16(8):2252-3. doi: 10.1111/ajt.13841. Epub 2016 May 25. Am J Transplant. 2016. PMID: 27108538 No abstract available.
Liver transplantation: Liver transplantation between an HIV-infected donor and HIV-infected recipient.
Leake I. Leake I. Nat Rev Gastroenterol Hepatol. 2016 Jun;13(6):314. doi: 10.1038/nrgastro.2016.81. Epub 2016 May 11. Nat Rev Gastroenterol Hepatol. 2016. PMID: 27165516 No abstract available.

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HIV-Positive-to-HIV-Positive Liver Transplantation

Collaborators

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HIV-Positive-to-HIV-Positive Liver Transplantation

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