Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan 23;16(1):e32971.
doi: 10.5812/hepatmon.32971. eCollection 2016 Jan.

Hepatitis Viruses B and D and Human Immunodeficiency Virus Infections in Hemodialysis Patients in the South of Iran: Prevalence and Genotypes

Fahime Bahri  1 , Ali Kargar Kheirabad  2 , Iman Ghasemzadeh  3 , Saeed Shoja  3 , Hamed Gouklani  4
Affiliations

Hepatitis Viruses B and D and Human Immunodeficiency Virus Infections in Hemodialysis Patients in the South of Iran: Prevalence and Genotypes

Fahime Bahri et al. Hepat Mon. .

Abstract

Background: Hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV) are transmitted by blood transfusion. Thus, hemodialysis (HD) patients are more prone to become the carriers of these infections due to their treatment demands.

Objectives: The aim of this study was to assess the prevalence of HBV and HIV infections among HD patients in Bandar Abbas, Iran, 2015.

Patients and methods: A total of 153 patients with chronic renal failure undergoing HD at Shahid Mohammadi hospital in Bandar Abbas were examined for hepatitis B surface antigen (HBsAg), anti- hepatitis C virus, and anti-HIV over a period of 2 months. Thereafter, all of the specimens were evaluated for HBV-DNA, HDV-RNA and HIV-RNA using polymerase chain reaction (PCR) and further techniques. All statistical analyses were carried out using SPSS version 12 for Windows with the t-test and chi-square (χ(2)) test.

Results: Both kinds of assay determined that nine (5.88%) patients were HBV positive (HBsAg-positive), whereas no HIV- and HDV-positive patients were diagnosed. All of the diagnosed HBV samples belonged to genotype D; the prevalence of HBV is associated with age, duration of HD, history of blood transfusion, and using shared HD devices.

Conclusions: In conclusion, the prevalence of HBV infection was low in the south of Iran, but genotype D represented the major HBV genotype in this population. Among the variables, age, duration of HD, history of blood transfusion, and using shared HD devices influenced the prevalence of HBV among HD patients.

Keywords: Hemodialysis; Hepatitis B Virus; Hepatitis D Virus; Human Immunodeficiency Virus.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. HBV PCR Products on Agarose Gel Electrophoresis
M, marker 100 bp; A, positive control; B-I, replicated regions in serum samples; J, negative control.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dodd RY. Current viral risks of blood and blood products. Ann Med. 2000;32(7):469–74. - PubMed
    1. Chow KM, Szeto CC, Wu AK, Leung CB, Kwan BC, Li PK. Continuous ambulatory peritoneal dialysis in patients with hepatitis B liver disease. Perit Dial Int. 2006;26(2):213–7. - PubMed
    1. Mayhall CG. Hospital epidemiology and infection control. Philadelphia: Lippincott Williams & Wilkins; 2012.
    1. Pérez ER. Catheter-Related Bloodstream Infections in Critical Care. INTECH Open Access Publisher; 2012.
    1. Mashragi F, Bernstein RS, Al-Mazroa M, Al-Tawfiq JA, Filemban S, Assiri A, et al. HIV transmission at a Saudi Arabia hemodialysis unit. Clin Infect Dis. 2014;59(6):897–902. doi: 10.1093/cid/ciu373. - DOI - PMC - PubMed

LinkOut - more resources