Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

Audrey Nailor¹, David A Walker², Thomas S Jacques³, Kathy E Warren⁴, Henry Brem⁵, Pamela R Kearns⁶, John Greenwood⁷, Jeffrey I Penny⁸, Geoffrey J Pilkington⁹, Angel M Carcaboso¹⁰, Gudrun Fleischhack¹¹, Donald Macarthur¹², Irene Slavc¹³, Lisethe Meijer¹⁴, Steven Gill¹⁵, Stephen Lowis¹⁵, Dannis G van Vuurden¹⁶, Monica S Pearl¹⁷, Steven C Clifford¹⁸, Sorana Morrissy¹⁹, Delyan P Ivanov¹², Kévin Beccaria²⁰, Richard J Gilbertson²¹, Karin Straathof²², Jordan J Green²³, Stuart Smith¹², Ruman Rahman¹², John-Paul Kilday²⁴

Affiliations

¹ Cancer Intelligence, 154 Cheltenham Road, Bristol, UK BS6 5RL.
² Children's Brain Tumour Research Centre, University of Nottingham, Room EE 1833a Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK NG7 2UH.
³ UCL Institute of Child Health, 30 Guilford St, London, UK WC1N 1EH.
⁴ National Cancer Institute, Building 10 - Hatfield CRC, Bethesda, MD 20892-1104.
⁵ Johns Hopkins University, 600 N Wolfe St, Baltimore, Maryland, USA, 21287.
⁶ Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT.
⁷ University College London, 11-43 Bath Street, London, UK EC1V 9EL.
⁸ University of Manchester, Stopford Building, Oxford Road, Manchester, UK M13 9PT.
⁹ University of Portsmouth, Winston Churchill Ave, Portsmouth, UK, PO1 2UP.
¹⁰ Institut de Recerca Pediatrica, Hospital Sant Joan de Déu, Barcelona, Spain.
¹¹ Essen University Hospital, Paediatrics III, Hufelandstraße 55, Essen, Germany 45147.
¹² University Hospital Nottingham, Derby Road, Nottingham, UK NG7 2UH.
¹³ Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
¹⁴ University Medical Centre Groningen, 1 Hanzeplein, Groningen, The Netherlands, 9713 GZ; University Hospital Nottingham, Derby Road, Nottingham, UK NG7 2UH.
¹⁵ Bristol Royal Hospital for Children, Upper Maudlin St, Bristol, UK, BS2 8BJ.
¹⁶ VU University Medical Centre, De Boelelaan 1118, Amsterdam, Netherlands, 1081 HZ.
¹⁷ Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Building 7218, Baltimore, Maryland, USA, 21287.
¹⁸ Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK, NE1 4LP.
¹⁹ The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, ON M5G 1X8.
²⁰ Pitié Salpetriere Hospital, Assistance Publique - Hôpitaux de Paris, 27 Rue Chaligny, Paris, France, 75012.
²¹ Cambridge Cancer Centre, 120 Cambridge Rd, Great Shelford, Cambridge UK, CB22 5JT.
²² Institute of Child Health, University College London, 30 Guilford Street, London, UK WC1N 1EH.
²³ Institute for NanoBioTechnology, Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, 400 N. Broadway/Smith Building Room 5017, Baltimore, MD 21231.
²⁴ Royal Manchester Children's Hospital, Oxford Rd, Manchester M13 9WL.

PMID: 27110286
PMCID: PMC4817522
DOI: 10.3332/ecancer.2016.630

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

Audrey Nailor et al. Ecancermedicalscience. 2016.

. 2016 Mar 31:10:630.

doi: 10.3332/ecancer.2016.630. eCollection 2016.

Authors

Affiliations

¹ Cancer Intelligence, 154 Cheltenham Road, Bristol, UK BS6 5RL.
² Children's Brain Tumour Research Centre, University of Nottingham, Room EE 1833a Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK NG7 2UH.
³ UCL Institute of Child Health, 30 Guilford St, London, UK WC1N 1EH.
⁴ National Cancer Institute, Building 10 - Hatfield CRC, Bethesda, MD 20892-1104.
⁵ Johns Hopkins University, 600 N Wolfe St, Baltimore, Maryland, USA, 21287.
⁶ Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT.
⁷ University College London, 11-43 Bath Street, London, UK EC1V 9EL.
⁸ University of Manchester, Stopford Building, Oxford Road, Manchester, UK M13 9PT.
⁹ University of Portsmouth, Winston Churchill Ave, Portsmouth, UK, PO1 2UP.
¹⁰ Institut de Recerca Pediatrica, Hospital Sant Joan de Déu, Barcelona, Spain.
¹¹ Essen University Hospital, Paediatrics III, Hufelandstraße 55, Essen, Germany 45147.
¹² University Hospital Nottingham, Derby Road, Nottingham, UK NG7 2UH.
¹³ Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
¹⁴ University Medical Centre Groningen, 1 Hanzeplein, Groningen, The Netherlands, 9713 GZ; University Hospital Nottingham, Derby Road, Nottingham, UK NG7 2UH.
¹⁵ Bristol Royal Hospital for Children, Upper Maudlin St, Bristol, UK, BS2 8BJ.
¹⁶ VU University Medical Centre, De Boelelaan 1118, Amsterdam, Netherlands, 1081 HZ.
¹⁷ Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Building 7218, Baltimore, Maryland, USA, 21287.
¹⁸ Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK, NE1 4LP.
¹⁹ The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, ON M5G 1X8.
²⁰ Pitié Salpetriere Hospital, Assistance Publique - Hôpitaux de Paris, 27 Rue Chaligny, Paris, France, 75012.
²¹ Cambridge Cancer Centre, 120 Cambridge Rd, Great Shelford, Cambridge UK, CB22 5JT.
²² Institute of Child Health, University College London, 30 Guilford Street, London, UK WC1N 1EH.
²³ Institute for NanoBioTechnology, Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, 400 N. Broadway/Smith Building Room 5017, Baltimore, MD 21231.
²⁴ Royal Manchester Children's Hospital, Oxford Rd, Manchester M13 9WL.

PMID: 27110286
PMCID: PMC4817522
DOI: 10.3332/ecancer.2016.630

Abstract

The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood-brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.

Keywords: CNS involvement; blood–brain barrier; brain tumours; drug delivery; glioma; medulloblastoma; paediatrics; translational medicine.

PubMed Disclaimer

References

1. “Children With Cancer UK | About Childhood Cancer”. [5 February 2016]. Childrenwithcancer.org.uk http://www.childrenwithcancer.org.uk/childhood-cancer.

Grants and funding

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

Affiliations

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

Authors

Affiliations

Abstract

References

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources