Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr 23:16:10.
doi: 10.1186/s12878-016-0051-y. eCollection 2016.

Characteristics of chronic lymphocytic leukemia in Senegal

Abibatou Sall  1 , Awa Oumar Touré  1 , Fatimata Bintou Sall  1 , Moussa Ndour  1 , Seynabou Fall  2 , Abdoulaye Sène  1 , Blaise Félix Faye  1 , Moussa Seck  1 , Macoura Gadji  1 , Tandakha Ndiaye Dièye  1 , Claire Mathiot  3 , Sophie Reynaud  4 , Saliou Diop  1 , Martine Raphaël  5
Affiliations

Characteristics of chronic lymphocytic leukemia in Senegal

Abibatou Sall et al. BMC Hematol. .

Abstract

Background: Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL is the most common type of leukemia in Western populations, the disease is rare in Africans. Hence, clinical and laboratory data and studies of CLL in Sub Saharan populations have been limited. The aims of this study were to analyze the characteristics of senegalese patients with CLL at the time of the diagnosis and to identify the correlation between clinical characteristics (Binet stage) with age, gender, laboratory parameters and chromosomal abnormalities.

Methods: In this study, we investigated the clinical and laboratory characteristics of CLL in Senegal. A total of 40 patients who had been diagnosed with CLL during the period from July 2011 to April 2015 in Senegal were evaluated. Cytology and immunophenotype were performed in all patients to confirm the diagnosis. The prognosis factors such as Binet staging, CD38 and cytogenetic abnormalities were studied. The statistical analysis was performed using STATA version 13 (Stata college station Texas). Each patient signed a free and informed consent form before participating in the study.

Results: The mean age was 61 years ranged from 48 to 85. There were 31 males and only 9 females (sex ratio M : F = 3,44). At diagnosic, 82.5 % of the patients were classified as having advanced Binet stages B or C. The prognosis marker CD38 was positive in 28 patients. Cytogenetic abnormalities studied by FISH were performed in 25 patients, among them, 68 % (17 cases) had at least one cytogenetic abnormality and 28 % had 2 simultaneous cytogenetic abnormalities.

Conclusion: Africans may present with CLL at a younger age and our data suggest that CLL in Senegal may be more aggressive than in Western populations.

Keywords: Chronic lymphocytic leukemia; Clinic; Cytogenetic abnormalities; Cytology; Immunophenotype.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a Bulky cervical lymph nodes. b Huge splenomegaly with splenic abcess. c Peripheral blood smear, typical small lymphocytes,with hypermature clumped chromatin and scanty cytoplasm. Presence of smudge cells (arrows). d Immunophenotype with CD38 positivity. e FISH, bi allelic deletion of 13q. f trisomy 12 (FISH)
See this image and copyright information in PMC

References

    1. National Cancer Institute: Surveillance, Epidemiology, and End Results: Populations (1969–2010). http://seer.cancer.gov.
    1. Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116(19):3724–34. doi: 10.1182/blood-2010-05-282632. - DOI - PubMed
    1. Molica S. Sex differences in incidence and outcome of chronic lymphocytic leukemia patients. Leuk Lymphoma. 2006;47:1477–1480. doi: 10.1080/10428190600555819. - DOI - PubMed
    1. Catovsky D, Wade R, Else M. The clinical significance of patients' sex in chronic lymphocytic leukemia. Haematologica. 2014;99(6):1088–94. doi: 10.3324/haematol.2013.101378. - DOI - PMC - PubMed
    1. Hallek M. Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am J Hematol. 2015;90(5):446–60. doi: 10.1002/ajh.23979. - DOI - PubMed