Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr 11;4(1):e000154.
doi: 10.1136/bmjdrc-2015-000154. eCollection 2016.

Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns-NHANES 2007-2012

Bingcao Wu  1 , Kelly Bell  2 , Amy Stanford  3 , David M Kern  1 , Ozgur Tunceli  1 , Suma Vupputuri  1 , Iftekhar Kalsekar  2 , Vincent Willey  1
Affiliations

Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns-NHANES 2007-2012

Bingcao Wu et al. BMJ Open Diabetes Res Care. .

Abstract

Objective: To describe the estimated prevalence and temporal trends of chronic kidney disease (CKD) treatment patterns, and the association between CKD and potential factors for type 2 diabetes mellitus (T2DM) in different demographic subgroups.

Research design and methods: This was a cross-sectional analysis of adults with T2DM based on multiple US National Health and Nutrition Examination Survey (NHANES) datasets developed during 2007-2012. CKD severity was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines using the CKD Epidemiology Collaboration (CKD-EPI) equation: mild to moderate=stages 1-3a; moderate to kidney failure=stages 3b-5. Multivariable logistic regression analyses were performed to assess the associations between CKD and potential factors.

Results: Of the adult individuals with T2DM (n=2006), age-adjusted CKD prevalence was 38.3% during 2007-2012; 77.5% were mild-to-moderate CKD. The overall age-adjusted prevalence of CKD was 40.2% in 2007-2008, 36.9% in 2009-2010, and 37.6% in 2011-2012. The prevalence of CKD in T2DM was 58.7% in patients aged ≥65 years, 25.7% in patients aged <65 years, 43.5% in African-Americans and Mexican-Americans, and 38.7% in non-Hispanic whites. The use of antidiabetes and antihypertensive medications generally followed treatment guideline recommendations. Older age, higher hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and having hypertension were significantly associated with CKD presence but not increasing severity of CKD.

Conclusions: CKD continued to be prevalent in the T2DM population; prevalence remained fairly consistent over time, suggesting that current efforts to prevent CKD could be improved overall, especially by monitoring certain populations more closely.

Keywords: Health Care Management; Kidney Disorder; Kidney Failure; Kidney Function Test.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Potential factors associated with the presence and severity of CKD in T2DM.
See this image and copyright information in PMC

References

    1. KDIGO 2012 Clinical Practice Guidelines for the Evaluation and Management of Chronic Kidney Disease. http://www.kdigo.org/clinical_practice_guidelines/pdf/CKD/KDIGO_2012_CKD.... (accessed 04 Jan 2016). - PubMed
    1. Afkarian M, Sachs MC, Kestenbaum B et al. . Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol 2013;24:302–8. 10.1681/ASN.2012070718 - DOI - PMC - PubMed
    1. Bailey RA, Wang Y, Zhu V et al. . Chronic kidney disease in US adults with type 2 diabetes: an updated national estimate of prevalence based on Kidney Disease: Improving Global Outcomes (KDIGO) staging. BMC Res Notes 2014;7:415 10.1186/1756-0500-7-415 - DOI - PMC - PubMed
    1. de Boer IH, Rue TC, Hall YN et al. . Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 2011;305:2532–9. 10.1001/jama.2011.861 - DOI - PMC - PubMed
    1. Koro CE, Lee BH, Bowlin SJ. Antidiabetic medication use and prevalence of chronic kidney disease among patients with type 2 diabetes mellitus in the United States. Clin Ther 2009;31:2608–17. 10.1016/j.clinthera.2009.10.020 - DOI - PubMed

LinkOut - more resources